Marlene Barros

Professor Catedrático

Professora Catedrática da Universidade Católica Portuguesa é licenciada em Biologia e doutorada em Bioquímica, especialidade de Enzimologia pela Universidade de Coimbra e realizou em 2007 na Universidade de Aveiro as Provas de Agregação em Biologia.

Em 1982 Inicia a carreira na Universidade de Aveiro, Departamento de Biologia. Coordenou o Mestrado em Microbiologia Molecular na mesma Universidade. Lecionou no Mestrado em Experimentação Animal da Faculdade de Medicina da Universidade de Coimbra.

Em 2001 integra a Universidade Católica Portuguesa como responsável pelas Ciências Básicas do curso de Medicina Dentária em Viseu. Leciona na UCP as UC de Biologia Celular, Bioquímica Estrutural e Imunobiologia.

Em 2009 cria a Licenciatura em Ciências Biomédicas, sendo coordenadora até ao presente. Em 2010 foi Diretora-Adjunta do Departamento de Ciências da Saúde da UCP. Desde 2015 é Diretora Regional do Instituto de Ciências da Saúde em Viseu.

É Diretora do Centro de Investigação Interdisciplinar em Saúde (CIIS) da UCP desde 2015.

O atual interesse de investigação centra-se na integração da informação sobre proteínas tendo como objetivo principal esclarecer mecanismos moleculares de doenças e identificar biomarcadores uteis para diagnóstico, ou como alvos terapêuticos.

Está particularmente interessada no diagnóstico em saliva e nesse sentido estabeleceu com financiamento de fundos regionais e europeus o laboratório SalivaTec.

Lidera ou colabora em vários projetos de investigação com financiamento por diferentes agências nacionais ou internacionais e tem larga experiencia na orientação de alunos de pós-doutoramento, doutoramento e mestrado.

Paper

# 10. Identificação na saliva de biomarcadores de suscetibilidade à cárie dentária

Rosa, N., Correia, M., Barros, M. , Carolina Lourenço. (2015). # 10. Identificação na saliva de biomarcadores de suscetibilidade à cárie dentária. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
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# 39. Identificação de biomarcadores salivares de doença periodontal em pacientes com gengivite

Rosa, N., Correia, M., Barros, M. , Beatriz Patrício Serra. (2015). # 39. Identificação de biomarcadores salivares de doença periodontal em pacientes com gengivite. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
Paper

#097. Presença de genes de resistência a antibióticos na cavidade oral: uma revisão sistemática

Rosa, N., Correia, M., Barros, M. , Sara Sousa. (2016). #097. Presença de genes de resistência a antibióticos na cavidade oral: uma revisão sistemática. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
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#145. Proteoma oral humano: da saliva ao diagnóstico das doenças cardiovasculares

Rosa, N., Correia, M., Barros, M. , Rafael Silva. (2016). #145. Proteoma oral humano: da saliva ao diagnóstico das doenças cardiovasculares. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
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#146. miRNAs salivares como biomarcadores da Diabetes Mellitus tipo II

Rosa, N., Correia, M., Barros, M. , Alexandra Martins. (2016). #146. miRNAs salivares como biomarcadores da Diabetes Mellitus tipo II. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
Paper

A New Enzyme Available for Peptide Synthesis

Barros, M. , Barros, M.. (1996). A New Enzyme Available for Peptide Synthesis. Peptides-european symposium-
Paper

Acetonitrile-induced unfolding of porcine pepsin A. A proposal for a critical role of hydration structures in conformational stability

Barros, M., Esteves, A. , Cardoso, T.. (2009). Acetonitrile-induced unfolding of porcine pepsin A. A proposal for a critical role of hydration structures in conformational stability. International Journal of Biological Macromolecules
Book

Activity of cardosins A and B in the presence of organic solvents

Barros, M. , Sarmento, A.C.. (1998). Activity of cardosins A and B in the presence of organic solvents. Progress in Biotechnology
Other

Biomarcadores salivares de pacientes periodontais com diabetes mellitus tipo 2

Barros, M. , Priscila Paganini Costa.Biomarcadores salivares de pacientes periodontais com diabetes mellitus tipo 2.
Paper

CanisOme - The protein signatures of Canis lupus familiaris diseases

Rosa, N., Correia, M., Barros, M. , Fernandes, M.. (2016). CanisOme - The protein signatures of Canis lupus familiaris diseases. Journal of Proteomics
Paper

Cardosin A as a model aspartic proteinase for the study of organic solvent effects: An overview on catalytic and structural aspects

Barros, M., Esteves, A. , Sarmento, A.C.. (2003). Cardosin A as a model aspartic proteinase for the study of organic solvent effects: An overview on catalytic and structural aspects. Journal of Molecular Catalysis B: Enzymatic
Paper

Cardosins A and B, two new enzymes available for peptide synthesis

Barros, M. , Ana Cristina Sarmento. (1998). Cardosins A and B, two new enzymes available for peptide synthesis. Journal of Molecular Catalysis B: Enzymatic
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Cardosins A and B, two new enzymes available for peptide synthesis

Barros, M. , Sarmento, AC. (1998). Cardosins A and B, two new enzymes available for peptide synthesis. Journal of Molecular Catalysis B-Enzymatic
Paper

Cardosins A and B, two new enzymes available for peptide synthesis

Barros, M., Esteves, A. , Sarmento, A.C.. (1998). Cardosins A and B, two new enzymes available for peptide synthesis. Journal of Molecular Catalysis - B Enzymatic
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Cardosins applied in neuronal embryonic cell culture: an efficient desegregation tool

Barros, M. , Duarte, A. S.. (2005). Cardosins applied in neuronal embryonic cell culture: an efficient desegregation tool. European Journal of Neurology
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Cardosins improve neuronal regeneration after cell disruption: A comparative expression study

Barros, M., Duarte, A. , Duarte, A.S.. (2009). Cardosins improve neuronal regeneration after cell disruption: A comparative expression study. Cell Biology and Toxicology
Paper

Cardosins: A new and efficient plant enzymatic tool to dissociate neuronal cells for the establishment of cell cultures

Rosa, N., Barros, M., Duarte, A. , Duarte, A.S.. (2007). Cardosins: A new and efficient plant enzymatic tool to dissociate neuronal cells for the establishment of cell cultures. Biotechnology and Bioengineering
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Comparasion of hydrolytic activity of cardosin A and B on Collagen i

Barros, M., Duarte, A. , Cabrita, A.M.S.. (1997). Comparasion of hydrolytic activity of cardosin A and B on Collagen i. FASEB Journal
Other

Computational Approach to Predict Inter-Species Oral Protein-Protein Interactions

Rosa, N., Barros, M. , Coelho, E. D.. (2013). Computational Approach to Predict Inter-Species Oral Protein-Protein Interactions. IWBBIO'13
Paper

Computational prediction of the human-microbial oral interactome

Rosa, N., Correia, M., Barros, M. , Coelho, E.D.. (2014). Computational prediction of the human-microbial oral interactome. BMC Systems Biology
Book

Data Integration Solution for Organ-Specific Studies: An Application for Oral Biology

Correia, M., Barros, M. , Melo, J.. (2013). Data Integration Solution for Organ-Specific Studies: An Application for Oral Biology. Communications in Computer and Information Science
Book Chapter

Data Integration Solution for Organ-Specific Studies: An Application for Oral Biology

Rosa, N., Barros, M. , Arrais, JoelP. (2013). Data Integration Solution for Organ-Specific Studies: An Application for Oral Biology. Biomedical Engineering Systems and Technologies
Paper

Effect of acetonitrile on Cynara cardunculus L. cardosin A stability

Barros, M., Esteves, A. , Shnyrova, A.V.. (2006). Effect of acetonitrile on Cynara cardunculus L. cardosin A stability. International Journal of Biological Macromolecules
Paper

Evaluation of cardosin A as a probe for limited proteolysis in non-aqueous environments - Complex substrates hydrolysis

Barros, M., Esteves, A., Duarte, A. , Sarmento, A.C.. (2006). Evaluation of cardosin A as a probe for limited proteolysis in non-aqueous environments - Complex substrates hydrolysis. Enzyme and Microbial Technology
Paper

Evaluation of cardosin A as a proteolytic probe in the presence of organic solvents

Barros, M., Esteves, A. , Sarmento, A.C.. (2004). Evaluation of cardosin A as a proteolytic probe in the presence of organic solvents. Journal of Molecular Catalysis B: Enzymatic
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Evaluation of the specificity of cardosin in peptide synthesis

Barros, M. , Barros, M.. (1996). Evaluation of the specificity of cardosin in peptide synthesis. FASEB Journal
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Expression of Genes Encoding Extracellular Matrix Macromolecules and Metalloproteinases in Avian Tibial Dyschondroplasia

Barros, M. , Velada, I.. (2011). Expression of Genes Encoding Extracellular Matrix Macromolecules and Metalloproteinases in Avian Tibial Dyschondroplasia. Journal of Comparative Pathology
Paper

From the salivary proteome to the OralOme: Comprehensive molecular oral biology

Rosa, N., Correia, M., Barros, M. , Rosa, N.. (2012). From the salivary proteome to the OralOme: Comprehensive molecular oral biology. Archives of Oral Biology
Paper

Functional and conformational changes in the aspartic protease cardosin A induced by TFE

Barros, M., Esteves, A. , Fraga, A.S.. (2012). Functional and conformational changes in the aspartic protease cardosin A induced by TFE. International Journal of Biological Macromolecules
Paper

Gingipains as a virulence factor in the oral cavity

Correia, M., Barros, M. , Campos Lopes, P.. (2012). Gingipains as a virulence factor in the oral cavity. Revista Portuguesa de Estomatologia, Medicina Dentaria e Cirurgia Maxilofacial
Paper

Happiness as a self-state and trait of consciousness: clinical hypnosis and saliva molecular biomarkers - a brief revision.

Rosa, N., Correia, M., & Barros, M. (2016). Happiness as a self-state and trait of consciousness: clinical hypnosis and saliva molecular biomarkers - a brief revision.. Experimental Pathology and Health Sciences. 2016;8 (1): 51-54
Other

Heterogeneity of a new aspartic proteinase from Cynara cardunculus L

Barros, M., Esteves, A. , Esteves, Ana Cristina. (2005). Heterogeneity of a new aspartic proteinase from Cynara cardunculus L. FEBS JOURNAL
Paper

How MMPs regulate avian endochondral ossification

Barros, M. , Velada, I. (2005). How MMPs regulate avian endochondral ossification. Febs Journal
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I-5. Que proteínas de origem microbiana existem na cavidade oral?

Rosa, N., Correia, M., Barros, M. , Maria dos Reis Pereira. (2013). I-5. Que proteínas de origem microbiana existem na cavidade oral?. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
Paper

I-6. Oraloma da Diabetes Melitos tipo 1 e 2 - um estudo comparativo

Rosa, N., Correia, M., Barros, M. , Vítor Daniel Moreira Brás. (2013). I-6. Oraloma da Diabetes Melitos tipo 1 e 2 - um estudo comparativo. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
Paper

Immobilisation of cardosin A in chitosan sponges as a novel implant for drug delivery

Barros, M., Duarte, A. , Pereira, A.O.. (2005). Immobilisation of cardosin A in chitosan sponges as a novel implant for drug delivery. Current Drug Discovery Technologies
Paper

Isolation and characterization of a bacteriocin-like peptide produced by Brevibacterium linens ATCC 9172, an orange cheese coryneform bacterium

Barros, M. , Oliveira, C.. (2002). Isolation and characterization of a bacteriocin-like peptide produced by Brevibacterium linens ATCC 9172, an orange cheese coryneform bacterium. Peptide Science—Present and Future
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Morphological evaluation of cardoon (Cynara cardunculus L.): assessing biodiversity for applications based on tradition, innovation and sustainability

Barros, M. , Barracosa, P.. (2018). Morphological evaluation of cardoon (Cynara cardunculus L.): assessing biodiversity for applications based on tradition, innovation and sustainability. Genetic Resources and Crop Evolution
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Multiplicity of aspartic proteinases from Cynara cardunculus L.

Barros, M., Esteves, A. , Sarmento, A.C.. (2009). Multiplicity of aspartic proteinases from Cynara cardunculus L.. Planta
Paper

New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach

Rosa, N., Correia, M., Barros, M. , Esteves, E.. (2017). New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach. BioMed Research International
Paper

Non-native states of cardosin A induced by acetonitrile: Activity modulation via polypeptide chains rearrangements

Barros, M., Esteves, A. , Oliveira, C.S.. (2009). Non-native states of cardosin A induced by acetonitrile: Activity modulation via polypeptide chains rearrangements. Journal of Molecular Catalysis B: Enzymatic
Paper

On the track for a hypothetical new cardosin?

Barros, M. , Cardoso, T. (2005). On the track for a hypothetical new cardosin?. Febs Journal
Paper

Oral microbial proteome: clues of OralCard

Rosa, N., Correia, M., Barros, M. , Correia, M.. (2012). Oral microbial proteome: clues of OralCard. Febs Journal
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OralCard: a bioinformatic tool dedicated to the oral cavity system

Rosa, N., Correia, M., Barros, M. , Rosa, N.. (2012). OralCard: a bioinformatic tool dedicated to the oral cavity system. Febs Journal
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OralCard: A bioinformatic tool for the study of oral proteome

Rosa, N., Correia, M., Barros, M. , Arrais, J.P.. (2013). OralCard: A bioinformatic tool for the study of oral proteome. Archives of Oral Biology
Paper

Peptide synthesis catalyzed by Cynara cardunculus L. Acid protease in aqueous-organic biphasic systems

Barros, M. , Barros, M.T.. (1993). Peptide synthesis catalyzed by Cynara cardunculus L. Acid protease in aqueous-organic biphasic systems. Biotechnology Letters
Paper

Protein Quality Assessment on Saliva Samples for Biobanking Purposes

Rosa, N., Correia, M., Barros, M. , Rosa, N.. (2016). Protein Quality Assessment on Saliva Samples for Biobanking Purposes. Biopreservation and Biobanking
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Reverse hydrolysis by cardosin A: Specificity considerations

Barros, M., Esteves, A. , Sarmento, A.C.. (2004). Reverse hydrolysis by cardosin A: Specificity considerations. Journal of Molecular Catalysis B: Enzymatic
Paper

SalivaPRINT Toolkit – Protein profile evaluation and phenotype stratification

Rosa, N., Barros, M. , Cruz, I.. (2018). SalivaPRINT Toolkit – Protein profile evaluation and phenotype stratification. Journal of Proteomics
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Specificity of Cardosins A and B in peptide synthesis

Barros, M. , Sarmento, AC. (1999). Specificity of Cardosins A and B in peptide synthesis. Peptide Science - Present and Future
Paper

Stability performance of Cynara cardunculus L. acid protease in aqueous-organic biphasic systems

Barros, M. , Barros, M.T.. (1992). Stability performance of Cynara cardunculus L. acid protease in aqueous-organic biphasic systems. Biotechnology Letters
Paper

The characterisation of the collagenolytic activity of cardosin A demonstrates its potential application for extracellular matrix degradative processes

Barros, M., Duarte, A. , Duarte, A.S.. (2005). The characterisation of the collagenolytic activity of cardosin A demonstrates its potential application for extracellular matrix degradative processes. Current Drug Discovery Technologies
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The landscape of protein biomarkers proposed for periodontal disease. Markers with functional meaning.

Barros, M. (2014). The landscape of protein biomarkers proposed for periodontal disease. Markers with functional meaning.. BioMed Research International
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The landscape of protein biomarkers proposed for periodontal disease: Markers with functional meaning

Rosa, N., Correia, M., Barros, M. , Rosa, N.. (2014). The landscape of protein biomarkers proposed for periodontal disease: Markers with functional meaning. BioMed Research International
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The role of MMPs in the progression of periodontitis in Portuguese individuals

Barros, M. , Fraga, AS. (2005). The role of MMPs in the progression of periodontitis in Portuguese individuals. Febs Journal
Paper

Thermostability of cardosin A from Cynara cardunculus L.

Barros, M., Esteves, A. , Pina, D.G.. (2003). Thermostability of cardosin A from Cynara cardunculus L.. Thermochimica Acta
Paper

Unfolding of cardosin A in organic solvents and detection of intermediaries

Barros, M., Esteves, A. , Sarmento, A.C.. (2009). Unfolding of cardosin A in organic solvents and detection of intermediaries. Journal of Molecular Catalysis B: Enzymatic
Other

Web information system for the study of oral health

Rosa, N., Correia, M., Barros, M. , Melo, J.. (2012). Web information system for the study of oral health. HEALTHINF 2012 - Proceedings of the International Conference on Health Informatics